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Vacation homes in Panama

212 homes published by their hosts. Enquire or book directly with the host.

Of these 212 homes, 12 have a private pool, 23 sleep at least 8, and 9 meet both requirements. Counts reflect host-published facts; missing details are not treated as confirmed amenities. Dates and prices are confirmed on each host’s booking site.

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212 homes · Panama

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Homey Duplex in Plaza Catedral

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 4

A 128 m², two-bedroom duplex spread over two levels in Plaza Catedral, within Panama City's UNESCO-listed historic quarter, with a king bed in each bedroom.

Book directwynwood-house.com

Intimate Loft in Santa Ana

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 23 m² open-plan loft in Santa Ana, Panama City, at the Avenida Central end of the old town, with a queen bed and full kitchen.

Book directwynwood-house.com

Light-filled 1BR in San Francisco w/ Pool

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A light-filled, 48-square-meter one-bedroom apartment in San Francisco, Panama City, towards Parque Omar, with a queen bed, full kitchen and access to a communal pool.

Book directwynwood-house.com

Luxury 1BR in Casco Antiguo w/ Balcony

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 56-square-meter, one-bedroom apartment with a balcony and a rooftop pool in the building, located in Casco Antiguo, Panama City's historic bayfront quarter.

Book directwynwood-house.com

Luxury 1BR in Casco Antiguo w/ Balcony & View

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 78 m² one-bedroom apartment with a balcony in Casco Antiguo, Panama City’s historic quarter, with a fully equipped kitchen and elevator access.

Book directwynwood-house.com

Luxury 1BR in Marbella w/ Balcony & View

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 94-square-meter, one-bedroom apartment with a balcony in Marbella, Panama City, by the Cinta Costera, with a rooftop pool, gym and sauna in the building.

Book directwynwood-house.com

Luxury 1BR in Santa Ana

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 54 m² one-bedroom apartment for two in Santa Ana, on Panama City's Avenida Central side, with a queen bed and a full kitchen.

Book directwynwood-house.com

Luxury 2BR in Casco Antiguo

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 4

A 154-square-meter, two-bedroom apartment in Panama City’s historic Casco Antiguo, with king and queen beds, a fully equipped kitchen, and a patio or balcony.

Book directwynwood-house.com

Luxury 2BR in Casco Antiguo w/ Rooftop

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 4

A 93 m² two-bedroom apartment with a rooftop pool in Casco Antiguo, Panama City's bayfront historic quarter, with a full kitchen and one queen bed per bedroom.

Book directwynwood-house.com

Marea 8 | Bocas Town

Bocas del Toro, Panama

1 bedroom · 3 beds · 1 bath·sleeps 3

Book directacomodorentals.com

Modern 1BR in San Francisco w/ Pool

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 48 m² one-bedroom apartment for two in San Francisco, Panama City, on the Parque Omar side of town, with a communal pool and gym.

Book directwynwood-house.com

Modern 2BR in Casco Antiguo w/ Balcony

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 4

A 98-square-meter, two-bedroom apartment with a balcony in Casco Antiguo, Panama City's bayfront historic quarter, with a full kitchen and building doorman.

Book directwynwood-house.com

Nácar 7 | Bocas Town

Bocas del Toro, Panama

1 bedroom · 2 beds · 1 bath·sleeps 4

Book directacomodorentals.com

Nature-Lover’s Bungalow with Nature View

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 4

A one-bedroom bungalow among Cerro Azul’s pine trees, with Lake Alajuela views, a balcony with a suspended rope bed, and shared outdoor gathering areas.

Book directwynwood-house.com

Peaceful 1BR in Plaza Catedral

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

An 84-square-meter, one-bedroom apartment in Plaza Catedral, with a king bed and full kitchen, set within Panama City’s UNESCO-listed historic quarter.

Book directwynwood-house.com

Penthouse Casco

Panama City, Panama

3 bedrooms · 3 beds · 4 baths·sleeps 6

A 420-square-meter, top-floor penthouse with three bedrooms in Casco Antiguo, Panama City's UNESCO-listed historic quarter, accommodating six guests with one king bed and two queen beds.

Book directwynwood-house.com

Perfect 2BR in Casco Antiguo w/ Balcony

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 4

A 70-square-meter, two-bedroom apartment with a balcony in Casco Antiguo, Panama City’s bayfront historic quarter, with a king bed in each bedroom.

Book directwynwood-house.com

Perfect Loft in Santa Ana

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 45 m² open-plan loft for two in Santa Ana, Panama City, at the Avenida Central end of the old town, with a queen bed and full kitchen.

Book directwynwood-house.com

Polished 1BR in Casco Antiguo w/ Balcony

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 63 m² one-bedroom apartment with a balcony and king bed in Casco Antiguo, Panama City’s UNESCO-listed historic quarter, accommodating up to two guests.

Book directwynwood-house.com

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