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Vacation homes in Panama

212 homes published by their hosts. Enquire or book directly with the host.

Of these 212 homes, 12 have a private pool, 23 sleep at least 8, and 9 meet both requirements. Counts reflect host-published facts; missing details are not treated as confirmed amenities. Dates and prices are confirmed on each host’s booking site.

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212 homes · Panama

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Deluxe 2BR in Casco Antiguo w/ Rooftop

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 4

A 105 m² two-bedroom apartment in Panama City’s historic Casco Antiguo, with a full kitchen, lift access and a rooftop pool in the building.

Book directwynwood-house.com

Deluxe 2BR in Costa del Este w/ Balcony

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 3

A 125 m² two-bedroom apartment with a balcony in Costa del Este, Panama City, beside the water and east of the city centre.

Book directwynwood-house.com

Deluxe Loft in Santa Ana

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 50 m² loft for two in Santa Ana, Panama City, near Avenida Central, with open-plan living and sleeping areas and a private entrance.

Book directwynwood-house.com

Dreamy Loft in Balboa w/ Cinta Costera Views

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 21 m² open-plan loft in Balboa, Panama City, with Cinta Costera views, a queen bed for two guests, and building amenities including a pool.

Book directwynwood-house.com

Eco 2BR Bungalow with Lush Nature Views

Las Escobas del Venado, Panama

2 bedrooms · 3 beds · 1 bath·sleeps 4

A two-bedroom bungalow with nature views in Playa Venao, featuring a large terrace, an outdoor shower, and access to a shared pool just steps from the beach.

Book directwynwood-house.com

Elegant 2BR in Panama Pacifico w/ Pool

Panama City, Panama

2 bedrooms · 4 beds · 2 baths·sleeps 4

A 65-square-meter, two-bedroom apartment for four guests in Panamá Pacífico, with a full kitchen and access to a building swimming pool in a planned canal-side community.

Book directwynwood-house.com

Elegant 2BR in San Francisco w/ Balcony

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 4

A 77 m² two-bedroom apartment with a balcony in San Francisco, Panama City, featuring queen beds and access to a building gym, pool and sauna.

Book directwynwood-house.com

Elegant 3BR in Casco Antiguo w/ Terrace

Panama City, Panama

3 bedrooms · 3 beds · 3 baths·sleeps 6

A 126-square-meter, three-bedroom apartment with a terrace in Casco Antiguo, Panama City's UNESCO-listed historic quarter, with a queen bed in each bedroom.

Book directwynwood-house.com

Enchanting 2BR in Casco Antiguo w/ Rooftop

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 4

A 115 m² two-bedroom apartment with a rooftop pool in Casco Antiguo, Panama City’s historic quarter on the bay, with a queen bed in each bedroom.

Book directwynwood-house.com

Enchanting 3BR in Casco Antiguo w/ Balcony

Panama City, Panama

3 bedrooms · 3 beds · 3 baths·sleeps 6

A 127 m² apartment with three queen bedrooms and a balcony in Casco Antiguo, Panama City's bayfront historic quarter, with colonial architecture, plazas and a lively dining scene.

Book directwynwood-house.com

Enchanting Loft in Santa Ana w/ Balcony

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 31-square-meter loft with a balcony in Santa Ana, Panama City, combining living and sleeping in an open-plan space near the historic quarter and bay.

Book directwynwood-house.com

Exclusive 2BR in Casco Antiguo

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 4

A 154-square-meter, two-bedroom apartment in Panama City's UNESCO-listed Casco Antiguo, with king and queen beds, a full kitchen and elevator access.

Book directwynwood-house.com

Exclusive 2BR in Marbella w/ Balcony

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 4

A 181 m² two-bedroom apartment with a balcony in Marbella, Panama City, featuring king and queen beds and a building with a rooftop pool, gym and sauna.

Book directwynwood-house.com

Gleaming 2BR w/ Balcony in San Francisco

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 4

An 83 m² two-bedroom apartment with a balcony in San Francisco, Panama City, east of the banking area, accommodating up to four guests.

Book directwynwood-house.com

Gorgeous 1BR in Casco Antiguo w/ Rooftop

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 66-square-meter, one-bedroom apartment with a rooftop pool and private entrance in Casco Antiguo, Panama City's UNESCO-listed historic quarter, accommodating up to two guests.

Book directwynwood-house.com

High-end 1BR in Casco Antiguo

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 79 m² one-bedroom apartment for two in Panama City’s bayfront Casco Antiguo, with a king bed, full kitchen and a balcony or patio.

Book directwynwood-house.com

High-end 1BR in Casco Antiguo w/ Balcony

Panama City, Panama

1 bedroom · 1 bed · 2 baths·sleeps 2

A 56-square-meter, one-bedroom apartment with a balcony in Casco Antiguo, Panama City, near the pedestrian shopping street of Avenida Central and the historic quarter.

Book directwynwood-house.com

High-end 1BR in Casco Antiguo w/ Rooftop

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

A 56 m² one-bedroom apartment in Panama City's historic Casco Antiguo, with a queen bed, a full kitchen and access to a rooftop pool in the building.

Book directwynwood-house.com

High-end 1BR in San Francisco w/ Balcony

Panama City, Panama

1 bedroom · 1 bed · 1 bath·sleeps 2

Bright 48 m² one-bedroom apartment with a balcony in Panama City's San Francisco district, offering a queen bed, a full kitchen and access to a communal pool.

Book directwynwood-house.com

High-end 2BR in Casco Antiguo w/ Rooftop

Panama City, Panama

2 bedrooms · 2 beds · 2 baths·sleeps 4

A 122-square-metre, two-bedroom apartment in Panama City's bayfront Casco Antiguo, with a full kitchen and a rooftop pool in the building.

Book directwynwood-house.com

High-end 2BR in Plaza Herrera

Panama City, Panama

2 bedrooms · 2 beds · 2.5 baths·sleeps 4

An 87-square-meter, two-bedroom apartment in Plaza Herrera, within Panama City's historic bayfront old town, with a queen bed in each bedroom and space for four guests.

Book directwynwood-house.com

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